Thomas-Tikhonenko Laboratory

Elena Sotillo, PhD

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Elena Sotillo received her PhD in molecular and Cellular Biology from the University of Navarra, Spain, where she focused on the involvement that telomerase activity has in the acquisition of metastasic capability in pediatric bone tumors (Sotillo-Pineiro et al, Ped Res 2004) and on the analysis of mutations affecting tumor suppressor genes and oncogenes as prognostic markers for survival and/or relapse in osteosarcomas and Ewing’s Sarcomas (Patino et al, Ped Res 1998; Patino et al, Mutat Res 1999; Patino et al, J Med Gen 2000). At the Fels Institute for Cancer Research and Molecular Biology (Temple University School of Medicine) Dr. Sotillo conducted studies on cell cycle regulation, focusing on the transition from quiescence into G1/S phases, and what molecular events are required to induce unscheduled proliferation and partial transformation of human primary cells (Sotillo et al, JBC 2008; Sotillo et al, JBC 2009; Rivadaneira et al, Gastroenterology 2010; Jayadeva et al, JBC 2010). Currently she is interested on the role that miRNAs play in c-Myc-induced cellular transformation, and how regulation of these miRNAs can be used as therapeutic tools for the treatment of hematological malignancies (Sotillo et al. Oncogene 2011, Sotillo & Thomas-Tikhonenko Phamacol Ther 2011).