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Edwin Horwitz, MD, PhD

Edwin Horwitz, MD, PhD

Attending physician

Associate Professor of Pediatrics, University of Pennsylvania School of Medicine

Contact Edwin Horwitz, MD, PhD

Resume

  • Department: Pediatrics
  • Division: Oncology
  • Primary Address:
    The Children's Hospital of Philadelphia
    Division of Oncology
    34th and Civic Center Blvd.
    Philadelphia, PA 19104

    Expertise

    The research of Dr. Horwitz focuses on the transplantation of marrow cells and mesenchymal stromal cells (MSCs) to treat cancer and genetic disorders of childhood.

    Appointments

    • Associate Professor of Pediatrics at the Children's Hospital of Philadelphia (2007 – 2013)

    Education

    • MD, Indiana University (1988)
    • PhD, Biochemistry, Indiana University (1985)
    • AB, Indiana University (1981)

    Extended Bio

    My specialty is bone marrow transplantation and cellular therapy to treat a wide variety of genetic disorders and cancers.

    With a background in stem cell biology, I'm working on new ways to cure children of terrible diseases. Taking care of the patient is the single most important thing I do. But since we can't cure every disease, clinical trials help us learn how to better take care of patients. We combine our state-of-the-art clinical care with the development of new approaches to treatment. I've always loved science and love taking care of kids and doing scientific research.

    Here at Children's Hospital, we pioneered the use of bone marrow cells to treat certain childhood cancers as well as certain genetic diseases. We are making great strides in making bone marrow transplantation more effective for a variety of patients.

    For patients and families, it's important to explain what we propose to do, what we offer, and why we are doing what we do. Patients are intimately involved in their medical care and are part of the team, as are their families. It's key to talk to the kids, not just to their parents. It helps the child bond with you when you explain what you are doing. And when patients aren't feeling well, they can better communicate this back to you.

    My research has pioneered the study of a certain kind of cell called mesenchymal stromal cells (MSC). These cells are able to support hematopoiesis (blood cell production.) I serve as director of the mesenchymal stem cell transplant program at Children's Hospital. We are proud to have been the leader of clinical applications of MSC during the last decade. We look at the cells in the laboratory to help translate their use at the bedside, and study their transplantation into patients to treat cancer and genetic disorders of childhood.

    Children's Hospital is a truly outstanding place for kids with a serious disease. If a child has an ear infection, every doctor is wonderful. But when the disease is more serious or even life-threatening, you want the child to be in a major medical institution with all the expert care options available. For kids who need bone marrow transplantation, Children's Hospital is that kind of place.

    Publications

    • Horwitz EM.. Binding and internalization of Glucogeon in isolated rat hepatocytes.. .
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WWK, Gordon PL, Neel MD, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK.. Mesenchymal cells, bone marrow transplantation, and osteogenesis imperfecta.. In: Corrections of Genetic Diseases by Transplantation V.. London: COGENT Press; .
    • Simmerman HK, Wang CC, Horwitz EM, Berzofsky JA, Gurd FR.. Semisynthesis of sperm whale myoglobin by fragment condensation.. Proc Natl Acad Sci USA. Vol 79. 1982:7739-7743.
    • Flanders KC, Horwitz EM, Gurd RS.. Semisynthetic derivatives of glucagon. The contribution of histidine-1 to hormone conformation and activity.. J Biol Chem. Vol 259. 1984:7031-7037.
    • Cornely KA, Shelter KA, England RD, Horwitz EM, Gurd RS.. Structure-function relationships of S-carboxymethyl methionine27 glucagon.. Arch Biochem Biophys. Vol 240. 1985:698-704.
    • Horwitz EM, Jenkins WT, Hoosein NM, Gurd RS.. Kinetic identification of a two-state glucagon receptor system in isolated hepatocytes. Interconversion of homogeneous receptors.. J Biol Chem. Vol 260. 1985:9307-9315.
    • Horwitz EM, Wyborski RJ, Gurd RS.. Partial agonism in the glucagon receptor system is a consequence of the two-state rat hepatic receptor.. J Biol Chem. Vol 261. 1986:13670-13676.
    • Horwitz EM, Gurd RS.. Quantitative analysis of internalization of glucagon by isolated hepatocytes.. Arch Biochem Biophys. Vol 267. 1988:758-769.
    • Wyborski RJ, Horwitz EM, Jenkins WT, Mormol JS, Gurd RS.. Guanine nucleotide regulation of the interconversion of the two-state hepatic glucagon receptor system of rat.. Arch Biochem Biophys. Vol 262. 1988:532-542.
    • Horwitz EM, Maloney KA, Ley TJ.. A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.. J Biol Chem. Vol 269. 1994:14130-14139.
    • Hongeng S, Krance RA, Bowman LC, Srivastava DK, Cunningham JM, Horwitz EM, Brenner MK, Heslop HE.. Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukaemia.. Lancet. Vol 350. 1997:767-771.
    • Horwitz EM.. Cell therapy for osteogenesis imperfecta.. In: Managing osteogenesis imperfecta: A medical manual. Gaithersburg, Maryland: Osteogenesis Imperfecta Foundation, Inc.; 1997.
    • Prockop DJ, Horwitz EM, Laptev A, Pereira R, Phinney D, Stokes D.. Marrow stromal cells as stem cells for continual renewal of non-hematopoietic tissues and as potential vectors for gene therapy.. In: Hematopoietic Microenvironment. Cambridge, England: Cambridge University Press.; 1998.
    • Ringwald-Smith K, Williams R, Horwitz EM.. Acute graft versus host disease of the intestines management by diet.. Oncology Nutrition Dietetic Practice Group Newsletter. 1998.
    • Stocks RM, Wang WC, Thompson JW, Stocks MC 2nd, Horwitz EM.. Malignant infantile osteopetrosis: otolaryngological complications and management.. Arch Otolaryngol Head Neck Surg. Vol 124. 1998:689-694.
    • Ringwald-Smith K, Williams R, Schmidt M, Horwitz EM.. Determination of energy expenditure in bone marrow transplant patients.. Nutri Clin Pract. Vol 13. 1998:215-218.
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK.. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta.. Nat Med. Vol 5. 1999:309-313.
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WWK, Marx JC, Brenner MK.. Osteogenesis imperfecta calls for caution.. Nat Med. Vol 5. 1999:466-467.
    • Marx JC, Allay JA, Persons DA, Nooner SA, Kelly PF, Vanin EF, Horwitz EM.. High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells.. Hum Gene Ther. Vol 10. 1999:1163-1173.
    • Heslop HE, Rill DR, Horwitz EM, Contant CF, Krance RA, Brenner MK.. Gene marking to assess tumor contamination in stem cell grafts for acute myeloid leukemia.. In: Autologous Blood and Marrow Transplantation.. Charlottesville, Virginia: Carden Jennings Publishing.; 1999:513-520.
    • Horwitz EM.. Scientific Committee on Mesenchymal Stem Cells.. Telegraft. Vol 6(1) . 1999.
    • Horwitz EM.. Bone Marrow Transplantation.. In: Childhood Cancer: A Handbook from St. Jude Children's Research Hospital with Contributions from St. Jude Clinicians and Scientists.. Cambridge, MA: Perseus Publishing.; 2000:305-309.
    • Horwitz EM.. Gene therapy applications using mesenchymal stem cells.. Graft. Vol 3. 2000:319-323.
    • Horwitz EM, Keating A.. Nonhematopoietic mesenchymal stem cells: what are they?. Cytotherapy. Vol 2. 2000:387-388.
    • Kerr NC, Wang WC, Mohadjer Y, Haik BG, Kaste SC, Horwitz EM.. Reversal of optic canal stenosis in osteopetrosis after bone marrow transplant.. Am J Ophthalmol. Vol 130. 2000:370-372.
    • Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, McCarville ME, Sussman M, Orchard PJ, Pyeritz RE, Brenner MK.. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.. Blood. Vol 97. 2001:1227-1331.
    • Steen RG, Helton KJ, Horwitz EM, Benaim E, Thompson S, Bowman LC, Krance R, Wang WC, Cunningham JM.. Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts.. Ann Neurol. Vol 49. 2001:222-229.
    • Snowden RT, Thompson JW, Horwitz E, Stocks RM.. The predictive value of serum interleukins in recurrent respiratory papillomatosis. A preliminary study.. Laryngoscope. Vol 111. 2001:404-408.
    • Hale GA, Tong X, Benaim E, Cunningham JM, Heslop HE, Horwitz EM, Leung W, Rochester RJ, Shearer PD, Srivastava DK, Woodard JP, Bowman LC.. Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation.. Bone Marrow Transplantation. Vol 27. 2001:155-162.
    • Leung WH, Turner V, Richardson SL, Benaim E, Hale G, Horwitz EM, Woodard P, Bowman LC.. Effect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors.. Hum Immunol. Vol 62. 2001:399-407.
    • Woodard P, Wang W, Pitte N, Benaim E, Horwitz E, Cunningham J, Bowman L.. Successful unrelated donor bone marrow transplantation for paroxysmal nocturnal hemoglobinuria.. Bone Marrow Transplantation. Vol 27. 2001:589-592.
    • Leung W, Pitts N, Burnette K, Cunningham JM, Horwitz EM, Benaim E, Hale G, Woodard P, Pui CH, Bowman LC.. Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome.. Bone Marrow Transplant. Vol 27. 2001:717-722.
    • Sobacchi C, Frattini A, Orchard P, Porras O, Tezcan I, Andolina M, Babul-Hirji R, Baric I, Canham N, Chitayat D, Dupuis-Girod S, Ellis I, Etzioni A, Fasth A, Fisher A, Gerritsen B, Gulino V, Horwitz E, Klamroth V, Lanino E, Mirolo M, Musio A, Matthijs G, Nonomaya S, Notarangelo LD, Ochs HD, Superti Furga A, Valiaho J, van Hove JL, Vihinen M, Vujic D, Vezzoni P, Villa A.. The mutational spectrum of human malignant autosomal recessive osteopetrosis.. Hum Mol Genet. Vol 10. 2001:1767-1773.
    • Davidoff AM, Ng CYC, Brown P, Leary MA, Spurbeck WW, Zhou J, Horwitz E, Vanin EF, Neinhuis AW.. Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice.. Clinical Cancer Res. Vol 7. 2001:2870-2879.
    • Horwitz EM.. Mesenchymal stem cells.. In: Color Atlas of Clinical Hematology, 3rd edition. St. Louis: Mosby; 2001:39.
    • Horwitz EM, Keating A.. Nonhematopoietic mesenchymal stem cells: recent progress and current controversies.. Telegraft. Vol 8. 2001:1-3.
    • Dominici M, Hoffman TJ, Horwitz EM.. Bone marrow mesenchymal cells: from biological properties to clinical applications.. J Biol Regul Homeost Agents. Vol 15. 2001:28-37.
    • Horwitz EM.. The clinical potential of mesenchymal stem cells.. Blood Therapies in Medicine. Vol 2. 2001:7-13.
    • Horwitz EM.. Marrow mesenchymal cell transplantation for genetic disorders of bone.. Cytotherapy. Vol 3. 2001:397-401.
    • Horwitz E, Prockop D, Keating A, Butcher B, Brenner M.. Mesenchymal and nonhematopoietic stem cells: recent progress and current controversies.. Cytotherapy. Vol 3. 2002:391-392.
    • Horwitz EM.. In Focus: Mesenchymal and nonhematopoietic stem cell therapy.. Cytotherapy. Vol 5. 2002:501.
    • Horwitz EM, Hofmann TJ, Garlits JE, Campioni D, Dominici M.. On the development of cell therapy for genetic disorders.. Cytotherapy. Vol 5. 2002:511-512.
    • Stocks R, Cannon CB, Wang WC, Horwitz EM, Thompson JW.. Reversal of obstructive sleep apena in osteopetrosis following bone marrow transplantation.. Clin Pediatr (Phila). Vol 41(1). 2002 Jan-Feb:55-7.
    • Horwitz EM, Gordon PL, Koo WKK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann TJ.. Isolated allogeneic bone marrow derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone.. Proc Natl Acad Sci USA. Vol 99. 2002:8932-8937.
    • Campioni D, Lanza F, Moretti S, Dominici M, Punturieri M, Pauli S, Hofmann T, Horwitz E, Castoldi G.. Functional and immunophenotypic characteristics of isolated CD105+ and fibroblast+ stromal cells from AML: implications for their plasticity along endothelial lineage.. Cytotherapy. Vol 5. 2003:66-79.
    • Hale GA, Bowman LC, Woodard JP, Cunningham JM, Benaim E, Horwitz EM, Heslop HE, Krance RA, Leung W, Shearer PD, Handgretinger R.. Allogeneic bone marrow transplantation for children with histiocytic disorders: use of TBI and omission of etoposide in the conditioning regimen.. Bone Marrow Transplant. Vol 31. 2003:981-986.
    • Frattini A, Pangrazio A, Susani L, Sobacchi C, Mirolo M, Abinun M, Andolina M, Flanagan A, Horwitz EM, Mihci E, Notarangelo LD, Ramenghi U, Teti A, Van Hove J, Vujic D, Young T, Orchard PJ, Vezzoni P, Villa A.. Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis.. J Bone Miner Res. Vol 10. 2003:1740-1747.
    • Woodard P, Tong X, Richardson S, Srivastava DK, Horwitz EM, Benaim E, Geiger T, Hale G, Leung W, Turner V, Cunningham J, Bowman L.. Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipients.. J Pediatr Hematol Oncol. Vol 12. 2003:955-959.
    • Hale GA, Rochester RJ, Heslop HE, Krance RA, Gingrich JR, Benaim E, Horwitz EM, Cunningham JM, Tong X, Srivastava DK, Leung WH, Woodard P, Bowman LC, Handgretinger R.. Hemorrhagic cystitis after allogeneic bone marrow transplantation in children: clinical characteristics and outcome.. Biol Blood Marrow Transplant. Vol 9. 2003:698-705.
    • Lowe EJ, Turner V, Handgretinger R, Horwitz EM, Benaim E, Hale GA, Woodard P, Leung W.. T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation.. Br J Haematol. Vol 123. 2003:323-326.
    • Horwitz EM.. Stem Cell Plasticity: A New Image of the Bone Marrow Stem Cell.. Current Opinion in Pediatrics. Vol 15. 2003:32-37.
    • Horwitz EM.. Bone marrow transplantation: it's not just about blood anymore!. Pediatric Transplantation. Vol 7 (Supp3). 2003:56-58.
    • Horwitz EM, Kasow KA, Hofmann TJ.. Clinical gene-marking of mesenchymal cells.. Cytotherapy. Vol 5. 2003:194-196.
    • Horwitz EM.. The road to developing successful mesenchymal stem cell therapy.. Telegraft. Vol 10. 2003:1-3.
    • Horwitz EM.. Stem cell plasticity: the growing potential of cellular therapy.. Arch Med Res. Vol 34. 2003:600-606.
    • Horwitz EM, Keating A.. The 3rd meeting on nonhematopoietic and mesenchymal stem cells.. Telegraft. Vol 10. 2004:17.
    • Horwitz EM.. Dkk-1-mediated expansion of adult stem cells.. Trends in Biotechnology. Vol 22. 2004:386-388.
    • Kasow KA, Bonfim C, Asch J, Margolis DA, Jenkins J, Tamburro RF, Handgretinger R, Horwitz EM.. Malignant infantile osteopetrosis and primary pulmonary hypertension: a new combination?. Pediatr Blood Cancer. Vol 42. 2004:190-194.
    • Woodard P, Cunningham JM, Benaim E, Chen X, Hale G, Horwitz E, Houston J, Kasow K, Leung W, Wang W, Yusuf U, Handgretinger R.. Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia.. Bone Marrow Transplant. Vol 33. 2004:411-418.
    • Woodard P, Helton K, McDaniel H, Khan RB, Thompson S, Hale G, Benaim E, Kasow K, Leung W, Horwitz E, Srivastava DK, Tong X, Yusuf U, Cunningham JM, Handgretinger R.. Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosis.. Bone Marrow Transplant. Vol 33. 2004:1151-1157.
    • Dominici M, Pritchard C, Garlits JE, Hofmann TJ, Persons DA, Horwitz EM.. Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation.. Proc Natl Acad Sci USA. Vol 101. 2004:11761-11766.
    • Dominici M, Tadjali M, Kepes S, Allay ER, Boyd K, Ney P, Horwitz E, Persons DA.. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny.. Genesis. Vol 42. 2005:17-22.
    • Pochampally RR, Horwitz EM, DiGirolamo CM, Stokes DS, Prockop DJ.. Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects.. Gene Ther. Vol 12. 2005:1119-1125.
    • Le Blanc K, Gotherstrom C, Ringden O, Hassan M, Jansson M, Horwitz E, Anneren G, Axelsson O, Dalton A, Ewald U, McMahon R, Norden-Lindeberg S, Nunn J, Astrom E, Westgren M.. Mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta.. Transplantation. Vol 79. 2005:1607-1614.
    • Woodard P, Barfield R, Hale G, Horwitz E, Leung W, Ribeiro R, Rubnitz J, Srivistava DK, Tong X, Yusuf U, Raimondi S, Handgretinger R, Cunningham J.. Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy related acute myelogenous leukemia or myelodysplastic syndrome.. Pediatric Blood and Cancer. 2005.
    • Hale GA, Bowman LC, Rochester RJ, Benaim E, Heslop HE, Krance RA, Horwitz EM, Cunningham JM, Tong X, Srivastava DK, Handgretinger R, Jones DP.. Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children.. Biol Blood Marrow Transplant. Vol 11. 2005:912-920.
    • Horwitz EM, Koo WWK, Fitzpatrick LA, Neel MD, Gordon PL.. Bone marrow cell therapy for genetic disorders of bone.. In: Regenerative and Cell Therapy.. Springer, Belin; 2005.
    • Church C, Santana VM, Hinds PS, Horwitz EM.. The Contested Border between 'Informal Research' and 'Innovative Care': Skirmishes over Roles, Responsibilities, and Resource Allocation.. In: Ethics and Research with Children: A Case Based Approach. Oxford University Press; 2005.
    • Horwitz EM, LeBlanc K, Dominici M, Mueller I, Slaper-Cortenback I, Marini FC, Deans RJ, Krause DS, Keating A.. Clarification of the Nomenclature for MSCs: The International Society for Cellular Therapy Position Statement. Cytotherapy. Vol 7. 2005:393-395.
    • Dominici M, LeBlanc K, Mueller I, Slaper-Cortenback I, Marini FC, Deans RJ, Krause DS, Keating A, Prockop DJ, Horwitz EM.. Minimal Defining Criteria for Multipotent Mesenchymal Stromal Cells (MSCs): The International Society for Cellular Therapy Position Statement.. Cytotherapy. Vol 8. 2006.
    • Horwitz EM, Keating A, Dominici M, Mueller I, Slaper-Cortenback I, Marini FC, Deans RJ, Krause DS, Prockop DJ, LeBlanc K.. Release Criteria for GMP Production of Multipotent Mesenchymal Stromal Cells (MSCs) for Clinical Trials: The International Society for Cellular Therapy Position Statement.. Cytotherapy. Vol 8. 2006.
    • Horwitz EM.. Fostering Translational Research of Mesenchymal Cell Therapy.. Telegraft. 2006.
    • Horwitz EM, Gordon PL.. Bone marrow mesenchymal stem cell transplantation for children with severe oteogenesis imperfecta.. In: Genetic Engineering of Mesenchymal Stem Cells. 2006.
    • Horwitz EM.. Future directions in pediatric stem cell transplantation.. In: Pediatric Bone Marrow Transplantation. Taylor & Francis Group, LLC; 2006.
    • Kasow KA, Leung W, Horwitz EM, Woodard P, Handgretinger R, Hale GA.. EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation.. Pediatr Blood Cancer. 2006.
    • Kaste SC, Kasow KA, Horwitz EM.. Quantitative bone mineral density assessment in malignant infantile osteopetrosis: QCT and DXA.. Pediatric Blood and Caner. 2006.
    • Kasow Kimberly A, Stocks Rose Mary S, Kaste Sue C, Donepudi Sreekrishna, Tottenham Dawn, Schoumacher Robert A, Horwitz Edwin M. Airway evaluation and management in 7 children with malignant infantile osteopetrosis before hematopoietic stem cell transplantation.. Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. Vol 30(3) . 2008 Mar:225-9.
    • Dominici Massimo, Marino Roberta, Rasini Valeria, Spano Carlotta, Paolucci Paolo, Conte Pierfranco, Hofmann Ted J, Horwitz Edwin M. Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation.. Blood. Vol 111(8) . 2008 Apr:4386-91.
    • Marino Roberta, Martinez Caridad, Boyd Kelli, Dominici Massimo, Hofmann Ted J, Horwitz Edwin M. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment.. Experimental hematology. Vol 36(3) . 2008 Mar:360-8.
    • Horwitz Edwin M, Prather William R. Cytokines as the major mechanism of mesenchymal stem cell clinical activity: expanding the spectrum of cell therapy.. The Israel Medical Association journal : IMAJ. Vol 11(4) . 2009 Apr:209-11.
    • Prather William R, Toren Amir, Meiron Moran, Ofir Racheli, Tschope Carsten, Horwitz Edwin M. The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia.. Cytotherapy. Vol 11(4) . 2009:427-34.
    • Dominici Massimo, Paolucci Paolo, Conte Pierfranco, Horwitz Edwin M. Heterogeneity of multipotent mesenchymal stromal cells: from stromal cells to stem cells and vice versa.. Transplantation. Vol 87(9 Suppl) . 2009 May:S36-42.
    • Dominici Massimo, Rasini Valeria, Bussolari Rita, Chen Xiaohua, Hofmann Ted J, Spano Carlotta, Bernabei Daniela, Veronesi Elena, Bertoni Filippo, Paolucci Paolo, Conte PierFranco, Horwitz Edwin M. Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation.. Blood. Vol 114(11) . 2009 Sep:2333-43.
    • Kasow Kimberly A, Krueger Jennifer, Srivastava Deo Kumar, Li Chenghong, Barfield Raymond, Leung Wing, Horwitz Edwin M, Madden Renee, Woodard Paul, Hussain Ishtiaq, McCarville M Beth, Handgretinger Rupert, Hale Gregory A. Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experience.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Vol 15(4) . 2009 Apr:490-5.
    • Jethva Reena, Otsuru Satoru, Dominici Massimo, Horwitz Edwin M. Cell therapy for disorders of bone.. Cytotherapy. Vol 11(1) . 2009:3-17.
    • Otsuru Satoru, Hofmann Ted J, Rasini Valeria, Veronesi Elena, Dominici Massimo, Horwitz Edwin M. Osteopoietic engraftment after bone marrow transplantation: effect of inbred strain of mice.. Experimental hematology. Vol 38(9) . 2010 Sep:836-44.
    • Chen Xiaohua, Hofmann Ted J, Otsuru Satoru, Jethva Reena, Lind Curt, Monos Dimitri, Horwitz Edwin M. A strategy for single nucleotide polymorphism analysis of chimerism for somatic cell therapy.. Cytotherapy. Vol 12(8) . 2010 Dec:1035-43.
    • Grisendi Giulia, Bussolari Rita, Cafarelli Luigi, Petak Istvan, Rasini Valeria, Veronesi Elena, De Santis Giorgio, Spano Carlotta, Tagliazzucchi Mara, Barti-Juhasz Helga, Scarabelli Laura, Bambi Franco, Frassoldati Antonio, Rossi Giulio, Casali Christian, Morandi Uliano, Horwitz Edwin M, Paolucci Paolo, Conte Pierfranco, Dominici Massimo. Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy.. Cancer research. Vol 70(9) . 2010 May:3718-29.
    • Jiang Qiujie, Oldenburg Reid, Otsuru Satoru, Grand-Pierre Alix E, Horwitz Edwin M, Uitto Jouni. Parabiotic heterogenetic pairing of Abcc6-/-/Rag1-/- mice and their wild-type counterparts halts ectopic mineralization in a murine model of pseudoxanthoma elasticum.. The American journal of pathology. Vol 176(4) . 2010 Apr:1855-62.
    • Pulsipher Michael A, Horwitz Edwin M, Haight Ann E, Kadota Richard, Chen Allen R, Frangoul Haydar, Cooper Laurence J N, Jacobsohn David A, Goyal Rakesh K, Mitchell David, Nieder Michael L, Yanik Gregory, Cowan Morton J, Soni Sandeep, Gardner Sharon, Shenoy Shalini, Taylor Douglas, Cairo Mitchell, Schultz Kirk R. Advancement of pediatric blood and marrow transplantation research in North America: priorities of the Pediatric Blood and Marrow Transplant Consortium.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Vol 16(9) . 2010 Sep:1212-21.
    • Turbeville Sean, Nicely Helen, Rizzo J Douglas, Pedersen Tanya L, Orchard Paul J, Horwitz Mitchell E, Horwitz Edwin M, Veys Paul, Bonfim Carmem, Al-Seraihy Amal. Clinical outcomes following hematopoietic stem cell transplantation for the treatment of mucopolysaccharidosis VI.. Molecular genetics and metabolism. Vol 102(2) . 2011 Feb:111-5.
    • Otsuru Satoru, Rasini Valeria, Bussolari Rita, Hofmann Ted J, Dominici Massimo, Horwitz Edwin M. Cytokine-induced osteopoietic differentiation of transplanted marrow cells.. Blood. Vol 118(8) . 2011 Aug:2358-61.
    • Sheen Cecilia, Vincent Tiffaney, Barrett David, Horwitz Edwin M, Hulitt Jessica, Strong Eliza, Grupp Stephan A, Teachey David T. Statins are active in acute lymphoblastic leukaemia (ALL): a therapy that may treat ALL and prevent avascular necrosis.. British journal of haematology. Vol 155(3) . 2011 Nov:403-7.
    • Horwitz Edwin M, Maziarz Richard T, Kebriaei Partow. MSCs in hematopoietic cell transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Vol 17(1 Suppl) . 2011 Jan:S21-9.
    • Horwitz Edwin M, Horowitz Mary M, DiFronzo Nancy L, Kohn Donald B, Heslop Helen E. Guidance for developing phase II cell therapy trial proposals for consideration by the Blood and Marrow Transplant Clinical Trials Network.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Vol 17(2) . 2011 Feb:192-6.
    • Stoyanova Radka, Pahlajani Niraj H, Egleston Brian L, Buyyounouski Mark K, Chen David Y T, Horwitz Eric M, Pollack Alan. The impact of dose-escalated radiotherapy plus androgen deprivation for prostate cancer using 2 linked nomograms.. Cancer. 2012 Oct.
    • Otsuru Satoru, Gordon Patricia L, Shimono Kengo, Jethva Reena, Marino Roberta, Phillips Charlotte L, Hofmann Ted J, Veronesi Elena, Dominici Massimo, Iwamoto Masahiro, Horwitz Edwin M. Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms.. Blood. Vol 120(9) . 2012 Aug:1933-41.
    • Kasow K A, Stewart C F, Barfield R C, Wright N L, Li C, Srivastava D K, Leung W, Horwitz E M, Bowman L C, Handgretinger R, Hale G A. A phase I/II study of CY and topotecan in patients with high-risk malignancies undergoing autologous hematopoietic cell transplantation: the St Jude long-term follow-up.. Bone marrow transplantation. Vol 47(11) . 2012 Nov:1448-54.
    • Otsuru Satoru, Hofmann Ted J, Olson Timothy S, Dominici Massimo, Horwitz Edwin M. Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device.. Cytotherapy. Vol 15(2) . 2013 Feb:146-53.
    • Rasini Valeria, Dominici Massimo, Kluba Torsten, Siegel Georg, Lusenti Giulia, Northoff Hinnak, Horwitz Edwin M, Schäfer Richard. Mesenchymal stromal/stem cells markers in the human bone marrow.. Cytotherapy. 2013 Jan.