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Goli Mostoufi-Moab, MD

Goli Mostoufi-Moab, MD

Attending physician

Assistant Professor, University of Pennsylvania School of Medicine

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Education

Education

The Pennsylvania State University - Hershey Medical Center, Hershey, Pa.

Internship

The Children's Hospital of Philadelphia, Philadelphia, Pa.

Residency

The Children's Hospital of Philadelphia, Philadelphia, Pa.

Fellowship

The Children's Hospital of Philadelphia, Philadelphia, Pa.

Board Certification

American Board of Pediatrics

Year Appointed

2009

Special Interests

Endocrine late effects in survivors of childhood cancer
Thyroid cancer

Research Interests

Bone health in survivors of bone marrow transplantation

Extended Bio

I have dual subspecialty training in the fields of pediatric endocrinology and oncology, with the focus of addressing treatment-related hormonal disorders in childhood cancer survivors.

The development of intensified oncology treatment regimens has greatly improved the survival of children with cancer. Currently, more than 80 percent of children with acute lymphoblastic leukemia (ALL) and upwards of 50 percent of pediatric patients treated for solid tumors will survive into adulthood. Similarly, five year cure rates for childhood Bone Marrow Transplantation (BMT) exceed 60 percent. It is estimated that in 2010, one in every 250 adults will be a survivor of childhood cancer. However, treatment-related disorders of endocrine systems such as growth hormone deficiency, thyroid disorders, infertility, obesity and poor bone health are common morbidities (diseases and conditions) facing this growing population of survivors.

Over the course of my unique dual training, I developed an interest in understanding childhood bone health and cancer treatment-related threats to childhood skeletal development. Cancer survivors are at risk for poor bone health, given their numerous endocrine morbidities. Skeletal development during childhood is characterized by specific changes in bone dimensions with coordinated actions of growth hormone and sex steroids in the setting of adequate biomechanical loading and nutrition.

Chemotherapy, irradiation, steroid exposure, poor muscle strength, vitamin D deficiency and poor nutrition all negatively impact the growing, vulnerable skeleton in this at-risk patient population. Understandably, a multidisciplinary team care approach is necessary to provide comprehensive care for this growing patient population with various treatment-related morbidities. I have been fortunate to be part of the wonderful Cancer Survivorship team at Children's Hospital in providing necessary care to our patients.

Children's Hospital houses one of the premier childhood cancer programs for research, training and comprehensive care in the world. The division of oncology treats many newly diagnosed patients from different regions each year, and also has a national referral base for complex cases. We have successfully integrated a state-of-the-art basic, translational and clinical research environment dedicated to eradicating the pain and suffering caused by cancer in children.

As a pediatric oncologist and endocrinologist at Children's Hospital, I have been blessed with outstanding individualized mentorship and role models in providing the best care for children with cancer. Treating children with cancer is my passion and addressing life-long treatment-related challenges in survivors of childhood cancer my ultimate goal. I am proud to be at Children's Hospital and part of the team.

Publications

Selected Publications

Awards

2007, Genetech Clinical Fellows Travel Grant Recipient
2004, William Pottash Fellow Teacher of the Year Award
2003, Children's Hospital of Philadelphia Physician Partnering Award
2000, Janet M. Glasgow Memorial Award
2000, Department of Pediatrics Award for Outstanding Achievement
2000, The Endocrine Society Medical Student Outstanding Achievement
2000, Medical Student Reserach Symposium Award
1998, Alpha Omega Alpha
1996-1999, Hammond Jr. Memorial Scholarship Award for Academic Achievement
1996, McGraw Hill Award for Academic Achievement

Leadership

Memberships in professional organizations

2010, American Society of Pediatric Hematology & Oncology
2010, American Society of Hematology
2006-present, Endocrine Society
2003, American Academy of Pediatrics
2000-present, American Medical Association

Original Papers

2011

Hobbie WL, Moab SM, Carlson CA, Gruccio D, Ginsberg JP. Prevalence of advanced bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma. Pediatr Blood Cancer. 2011 Mar;56(3):474-6. Cited in PubMed: PMID 21072832.

2010

Mostoufi-Moab S, Grimbery A. Pediatric brain tumor treatment: growth consequences and their management. Pediatr Endocrinol Rev. 2010 Sep;8(1):6-17. Cited in PubMed: PMID 21037539.

Werner AH, Scarfone R, Mostoufi-Moab S. A febrile young infant with splenomegaly and ecchymoses. Pediatr Emerg Care. 2010 Jun;26(6):442-4. Cited in PubMed: PMID 20531132.

Leonard MB, Elmi A, Mostoufi-Moab S, Shults J, Burnham JM, Thayu M. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metal, 2010 Apr;9(4):1681-9. Epub 2010 Feb 15. Cited in PubMed: PMID 20157194.

Posters and Presentations

2009

Mostoufi-Moab S. Bone health beyond cancer therapy [invited lecture]. The Children's Hospital of Philadelphia/ 2009 May; Philadelphia, Pa.