- Primary Address:
Hospital of the University of Pennsylvania
Cardiovascular Medicine Division
3400 Spruce St.
9018 Gates Pavilion
Philadelphia, PA 19104
- (215) 662-2285
Director, Noninvasive Imaging
CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Biotechnology / Nanomedicine / Imaging
CVI Research Description:
My longstanding interests is in using cardiovascular imaging to investigate left ventricular remodeling. This has involved using Doppler echocardiography in large clinical trials accessing the efficacy of pharmaceutical interventions (ACE inhibitors and beta blockers post infarction) and the role of devices including epicardial and endocardial restraint. More recently I am studying the role of cardiac resynchronization and reverse remodeling with advanced heart failure (MIRACLE, MIRACLE ICD, BLOCK-HF and REVERSE Trials).
I also direct the quantitative echocardiographic core laboratory in a number of additional clinical trials that have involved quantitative imaging.
Dr. Fisher is interested in the management of brain tumors and tumors related to neurofibromatosis type 1 and in new imaging modalities for evaluation of plexiform neurofibromas and brain tumors.
- Associate Professor of Pediatrics at the Children's Hospital of Philadelphia (2012 – present)
- Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (2003 – 2012)
- John W. Bryfogle Professor of Medicine, University of Pennsylvania School of Medicine (1993 – present)
- Assistant Professor of Medicine, University of Pennsylvania School of Medicine (1980 – 1984)
- M.D., Harvard Medical School (cum Laude) (1994)
- FRCP, Royal College of Physicians, London, UK (1993)
- FESC, Fellow of the European Society of Cardiology (1991)
- B.A., Psychology, Summa cum Laude, Amherst College (1989)
- FACC, American College of Cardiology (1984)
- MRCP, Royal College of Physicians, London, UK (1973)
- MBBS, Guys Hospital Medical School, London, UK (1970)
- BSc, Guys Hospital Medical School, London, UK (1967)
I am part of the Hematologic Malignancies group at Children's Hospital, which focuses on the care of children with leukemia, lymphoma and related diseases. My particular clinical focus is on acute lymphoblastic leukemia, the most common type of childhood cancer. My goal, along with my colleagues, is to provide the best possible care for children with cancer, whether at initial diagnosis or when relapse or problems with treatment occur. This means making available treatments that are based on current research as well as established standards.
In addition to having medical expertise, it’s also important to provide compassionate and responsive care for patients and their families--at times which can be very stress-filled and confusing. Part of my role is to insure that families are well-informed about the treatment their child receives and are comfortable with the choices they make. This helps ensure they can participate as an active part of the care team. It extends to treatment decisions as well as to supporting quality of life and normal development despite medical needs. To develop better ways to cure cancer in children, we need to learn more about how leukemias and lymphomas behave--often referred to as disease biology--and about the actual effectiveness and risks of different treatment strategies for patients. This area includes both clinical trials and outcomes research.
My background is in biomedical informatics, which is the use of information technology and computer science to answer questions about medicine, ranging from molecular biology to quality of care. I strongly believe it's possible to improve clinical care by gathering more appropriate information and providing better ways to organize that information for the clinicians making patient decisions. My research focuses on different aspects of this question. I am part of the team at Children's Hospital working to develop the Pediatric Electronic Data Sharing Network (PEDSNet). This collaboration among children’s hospitals is dedicated to using information from electronic medical records to perform more accurate outcomes and quality research than is possible using currently available information. I am also working with a multi-specialty group at Children's Hospital to develop new ways to collect medical information and present it to clinicians at the time of a clinic visit to enable them to make better decisions about patient care.
There is a practical dimension to medical informatics as well. To make well-informed decisions, clinicians must be able to: gather accurate information; have organized ways to look at whether current practice is safe and effective and how it could be improved; and must have tools to provide the right information when decisions are being made. To help achieve these goals at Children's Hospital, I have committed a significant part of my work to building the Epic electronic health record for care of oncology patients and other acutely ill children at CHOP.
I also serve on the oncology quality improvement and clinical care committees, co-chair the chemotherapy safety committee and represent our group on Children's Hospital’s bloodstream infection steering group and the NACHRI hematology/oncology collaborative for reducing bloodstream infections. Each of these groups is committed to making care of children safer and more reliable. We are finding ways to reduce harm to patients--both errors and side effects of treatment--and improve adoption of practices that have been shown to be more effective.
One of the phrases we use to describe our commitment to our patients is “caring for your child like I would care for my own child.” This sets a high standard, but I believe we would not be justified in seeking anything less. My hope is that through this combination of clinical, research and administrative work I can help to maintain pediatric care for children, not only here at Children's Hospital but elsewhere--at a level I would be happy for my family to receive.
- Hwang EI, Jakacki RI, Fisher MJ, Kilburn LB, Horn M, Vezina G, Rood BR, Packer RJ. Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatric Blood & Cancer. 2013 September.
- Avery RA, Ferner RE, Listernick R, Fisher MJ, Gutmann DH, Liu GT.. Visual Acuity in Children with Low Grade Gliomas of the Visual Pathway: Implications for Patient Care and Clinical Research. Journal Neurooncology. Vol 110(1-7) . 2012.
- Lang SS, Beslow LA, Gabel B, Judkins AR, Fisher MJ, Sutton LN, Storm PB, Heuer GG. Surgical Treatment of Brain Tumors in Infants Less than 6 months of Age and Literature Review. World Neurosurgery. Vol 78(1-2) . 2012:137-44.
- Campen CJ, Kranick SM, Kasner SE, Kessler SK, Zimmerman RA, Lustig L, Phillips PC, Storm PB, Smith SE, Ichord R, Fisher MJ. Cranial Irradiation Increases Risk of Stroke in Pediatric Brain Tumor Survivors. Stroke. Vol 43. 2012:3035-3040.
- Johnson KJ, Fisher MJ, Listernick RL, North KN, Schorry EK, Viskochil D, Weinstein M, Rubin JB, Gutmann DH. Parent of Origin and Sex Effects in Children with NF1 and Optic Gliomas.. Familial Cancer. Vol 11(4) . 2012:653-6.
- Fisher MJ, Loguidice M, Gutmann DH, Listernick R, Ferner RE, Ullrich NJ, Packer RJ, Tabori U, Hoffman RO, Ardern-Holmes SL, Hummel TR, Hargrave DR, Bouffet E, Charrow J, Bilaniuk LT, Balcer LJ, Liu GT.. Visual Outcomes in Children with Neurofibromatosis Type 1 Associated Optic Pathway Glioma Following Chemotherapy: A Multi-center Retrospective Analysis. Neuro-Oncology. Vol 14(6) . 2012:790-797.
- Avery RA, Liu GT, Fisher MJ, Quinn GE, Belasco JB, Phillips PC, Maguire MG, Balcer LJ.. Retinal Nerve Fiber Layer Thickness in Children with Optic Pathway Gliomas.. American Journal of Ophthalmology. Vol 151. 2011:542-549.
- Palmer Shawna L, Hassall Tim, Evankovich Karen, Mabbott Donald J, Bonner Melanie, Deluca Cinzia, Cohn Richard, Fisher Michael J, Morris E Brannon, Broniscer Alberto, Gajjar Amar. Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma.. Neuro-Oncology. 2010 Aug.
- Packer Roger J, Jakacki Regina, Horn Marianna, Rood Brian, Vezina Gilbert, MacDonald Tobey, Fisher Michael J, Cohen Bruce. Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan.. Pediatric Blood & Cancer. Vol 52(7) . 2009 Jul:791-5.
- Chi Susan N, Zimmerman Mary Ann, Yao Xiaopan, Cohen Kenneth J, Burger Peter, Biegel Jaclyn A, Rorke-Adams Lucy B, Fisher Michael J, Janss Anna, Mazewski Claire, Goldman Stewart, Manley Peter E, Bowers Daniel C, Bendel Anne, Rubin Joshua, Turner Christopher D, Marcus Karen J, Goumnerova Liliana, Ullrich Nicole J, Kieran Mark W. Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor.. Journal of Clinical Oncology. Vol 27(3) . 2009 Jan:385-9.