L. Charles Bailey, MD, PhD

Attending physician
Assistant professor of pediatrics, University of Pennsylvania School of Medicine

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Oncology/CTRB 10 Children's Hospital of Philadelphia 3501 Civic Center Blvd.
(267) 426-3184


Dr. Bailey is a member of the Divisions of Oncology and Hematology at CHOP.

As part of the general oncology group, he cares for patients with a variety of tumors. His focus is on leukemia and lymphoma, and particularly on acute lymphoblastic leukemia, the most common type of childhood cancer. In addition to caring for patients on the inpatient service and in clinic, Dr. Bailey serves as part of the steering committee for the division's Leukemia/Lymphoma Group.

Dr. Bailey's practice in hematology includes patients with sickle cell disease, bleeding or clotting disorders, bone marrow failure, and general hematologic problems. His special interests are in sickle cell disease and bone marrow failure. He attends on both the inpatient service and in clinic.

Use of health information, particularly EHR-derived data, to improve the effectiveness of clinical research and the quality of pediatric care.

Clinical information systems, especially the electronic health record, provide an unparalleled opportunity to improve care through decision support. However, taking advantage of this opportunity requires a carefully designed information technology infrastructure. In order to help realize this, Dr. Bailey is involved in the building of the Epicare electronic health record for acute care at CHOP, and particularly in its implementation for Oncology patients, including the Beacon chemotherapy management module.

Dr. Bailey also sits on the hospital's Clinical Decision Support committee, and the Division of Oncology's chemotherapy safety and quality improvement committees.

Our research is based on the proposition that the quality of pediatric health care, and the overall health of children, can be improved by intelligent use of clinical and research information. Large and rapidly growing pools of information about current clinical practice already exist in electronic form; their use is limited by differences in data models, and the lack of pathways to securely retrieve and analyze data. Increasing use of the electronic health record in clinical settings provides both a richer variety of accessible data, and an opportunity to provide intelligent decision support to clinicians at the point of care.

We are developing new ways to translate information into better care at several levels:
- Building accurate and complete sets of clinical data for large pediatric populations. This includes work on constructing a comprehensive data trust within the CHOP network, to serve as infrastructure for many decision support projects, and the establishment of a multicenter collaborative for exchange of pediatric health data.

- Developing tools to improve utility of information and decision support at the point of care. Work here includes development of a clinical episode grouper, with initial deployment to primary care practices in a trial of decision support for treatment of otitis media. We are also developing an electronic system to track chemotherapy planning and delivery for oncology patients, in order to improve safety in this practice.

- Analyzing the impact of clinical decision support on practice. Both the otitis media and chemotherapy tracking projects include an assessment of changes in practice patterns and error rates after the decision support intervention becomes available.


Assistant Professor of Clinical Pediatrics at University of Pennsylvania School of Medicine (2008– present)


M.D., Medicine, University of Pennsylvania School of Medicine (1998)
Ph.D., Cellular & Molecular Biology, University of Pennsylvania School of Medicine (1998)
A.B., 1. Classics 2. Biochemistry, Washington University in St. Louis (1986)

Extended Bio

I am part of the Hematologic Malignancies group at Children's Hospital, which focuses on the care of children with leukemia, lymphoma and related diseases. My particular clinical focus is on acute lymphoblastic leukemia, the most common type of childhood cancer. My goal, along with my colleagues, is to provide the best possible care for children with cancer, whether at initial diagnosis or when relapse or problems with treatment occur. This means making available treatments that are based on current research as well as established standards.

In addition to having medical expertise, it’s also important to provide compassionate and responsive care for patients and their families--at times which can be very stress-filled and confusing. Part of my role is to insure that families are well-informed about the treatment their child receives and are comfortable with the choices they make. This helps ensure they can participate as an active part of the care team. It extends to treatment decisions as well as to supporting quality of life and normal development despite medical needs. To develop better ways to cure cancer in children, we need to learn more about how leukemias and lymphomas behave--often referred to as disease biology--and about the actual effectiveness and risks of different treatment strategies for patients. This area includes both clinical trials and outcomes research.

My background is in biomedical informatics, which is the use of information technology and computer science to answer questions about medicine, ranging from molecular biology to quality of care. I strongly believe it's possible to improve clinical care by gathering more appropriate information and providing better ways to organize that information for the clinicians making patient decisions. My research focuses on different aspects of this question. I am part of the team at Children's Hospital working to develop the Pediatric Electronic Data Sharing Network (PEDSNet). This collaboration among children’s hospitals is dedicated to using information from electronic medical records to perform more accurate outcomes and quality research than is possible using currently available information. I am also working with a multi-specialty group at Children's Hospital to develop new ways to collect medical information and present it to clinicians at the time of a clinic visit to enable them to make better decisions about patient care.

There is a practical dimension to medical informatics as well. To make well-informed decisions, clinicians must be able to: gather accurate information; have organized ways to look at whether current practice is safe and effective and how it could be improved; and must have tools to provide the right information when decisions are being made. To help achieve these goals at Children's Hospital, I have committed a significant part of my work to building the Epic electronic health record for care of oncology patients and other acutely ill children at CHOP.

I also serve on the oncology quality improvement and clinical care committees, co-chair the chemotherapy safety committee and represent our group on Children's Hospital’s bloodstream infection steering group and the NACHRI hematology/oncology collaborative for reducing bloodstream infections. Each of these groups is committed to making care of children safer and more reliable. We are finding ways to reduce harm to patients--both errors and side effects of treatment--and improve adoption of practices that have been shown to be more effective.

One of the phrases we use to describe our commitment to our patients is “caring for your child like I would care for my own child.” This sets a high standard, but I believe we would not be justified in seeking anything less. My hope is that through this combination of clinical, research and administrative work I can help to maintain pediatric care for children, not only here at Children's Hospital but elsewhere--at a level I would be happy for my family to receive.


Selected Publications

Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.. Blood. Vol 114(5) . 2009 Jul:983-94.
Bailey, LC, Reilly, AF, Rheingold, SR. Infections in Pediatric Patients with Hematologic Malignancies. Seminars in Hematology. Vol 46(3) . 2009 July:313-24.
Bailey L Charles, Lange Beverly J, Rheingold Susan R, Bunin Nancy J. Bone-marrow relapse in paediatric acute lymphoblastic leukaemia.. The lancet oncology. Vol 9(9) . 2008 Sep:873-83.
Master Stephen R, Stoddard Alexander J, Bailey L Charles, Pan Tien-Chi, Dugan Katherine D, Chodosh Lewis A. Genomic analysis of early murine mammary gland development using novel probe-level algorithms.. Genome biology. Vol 6(2) . 2005 Feb:R20.
Bailey L C, Searls D B, Overton G C. Analysis of EST-driven gene annotation in human genomic sequence.. Genome research. Vol 8(4) . 1998 Apr:362-76.
Bailey L C, Fischer S, Schug J, Crabtree J, Gibson M, Overton G C. GAIA: framework annotation of genomic sequence.. Genome research. Vol 8(3) . 1998 Mar:234-50.
Bedian V, Adams T, Geiger E A, Bailey L C, Gasser D L. A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC.. Immunogenetics. Vol 46(5) . 1997:427-30.
Budarf M L, Collins J, Gong W, Roe B, Wang Z, Bailey L C, Sellinger B, Michaud D, Driscoll D A, Emanuel B S. Cloning a balanced translocation associated with DiGeorge syndrome and identification of a disrupted candidate gene.. Nature genetics. Vol 10(3) . 1995 Jul:269-78.
Feldman G J, Robin N H, Brueton L A, Robertson E, Thompson E M, Siegel-Bartelt J, Gasser D L, Bailey L C, Zackai E H, Muenke M. A gene for cleidocranial dysplasia maps to the short arm of chromosome 6.. American journal of human genetics. Vol 56(4) . 1995 Apr:938-43.
Attree O, Olivos I M, Okabe I, Bailey L C, Nelson D L, Lewis R A, McInnes R R, Nussbaum R L. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase.. Nature. Vol 358(6383) . 1992 Jul:239-42.
Schnur R E, Wick P A, Bailey C, Rebbeck T, Weleber R G, Wagstaff J, Grix A W, Pagon R A, Hockey A, Edwards M J. Phenotypic variability in X-linked ocular albinism: relationship to linkage genotypes.. American journal of human genetics. Vol 55(3) . 1994 Sep:484-96.