Assistant professor of Pediatrics, University of Pennsylvania School of Medicine
Children's Hospital of Philadelphia
Colket Translational Research Building, Rm 4064
3501 Civic Center Blvd
Philadelphia, PA 19104
University of Liege, Belgium, 1998.
Master (of Science)
University of Liege, Belgium, 1999.
University of Liege, Belgium, 2004.
Hematopoietic Stem Cell Biology
Liver Stem/Progenitor Cell Biology
Retinoblastoma and the Rb pathway
Viatour P and Sage J: Newly identified aspects of tumor suppression by Rb. Disease Models and Mechanisms 4 (5), 2011.
Viatour P, Saddic L, Elhmer U, Lin C, Dorrell C, Andersen JB, Schaffer B, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, and Sage J.: Notch signaling suppresses hepatocellular carcinoma initiated from mouse adult liver progenitors following inactivation of the Rb family. Journal of Experimental Medicine 208 (10): 1963-76, September 2011.
Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ.: MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res. 21(5): 798-810, 2011.
Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, Sage J.: G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol. 191(4): 809-25, 2010.
Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegue E and Sage J.: Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3(4): 416-428, 2008.
Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y.: pRb family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes and Development 21(1): 49-54, 2007.
Viatour P, Merville MP, Bours V and Chariot A.: Phosphorylation of NF-κB/IκB proteins: implications in cancer and inflammation. Trends in Biochemical Sciences 30(1): 43-52, 2005.
Viatour P, Dejardin E, Warnier M, Lair F, Claudio E, Bureau F, Marine JC, Merville MP, Maurer U, Green DR, Piette J, Siebenlist U, Bours V and Chariot A.: GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Molecular Cell 16(1): 35-45, 2004.
Viatour P, Bentires-Alj M, Chariot A, Deregowski V, de Leval L, Merville MP and Bours V.: NF-kappaB2/p100 induces Bcl-2 expression. Leukemia 17(7): 1349-1356, 2003.
Viatour P, Legrand-Poels S, Van Lint C, Warnier M, Merville MP, Gielen J, Piette J, Bours V and Chariot A.: Cytoplasmic IkappaBalpha increases NF-kappaB independent transcription through binding to HDAC1 and HDAC3. Journal of Biological Chemistry 278(47): 46541-46548, 2003.