3400 SPRUCE ST.
Pediatric Neuro-Oncology experimental therapeutics
- Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1991 – 1995)
- Assistant Professor of Neurology at University of Pennsylvania School of Medicine (1991 – 1995)
- Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (1995 – 2000)
- Associate Professor of Neurology at the Children's Hospital of Philadelphia (1995 – 2000)
- Professor of Pediatrics at University of Pennsylvania School of Medicine (2000– present)
- Professor of Neurology at the Children's Hospital of Philadelphia (2000– present)
- M.D., University of Connecticut School of Medicine (1978)
- B.A., Philosophy, Oberlin College (1974)
Specialties and Services
University of Connecticut School of Medicine, Farmington, Conn.
Memorial Sloan-Kettering Cancer Center,NY
New York Hospital, NY
Neurological Institute of New York, NY
Children's Hospital, Boston, Mass.
American Board of Pediatrics
American Board of Psychiatry and Neurology/Child Neurology
Research in neuro-oncology and cellular mechanisms of neurotoxicity
Stokes research summary
Retinal nerve fiber layer thickness in children with optic pathway gliomas.
Avery RA, Liu GT, Fisher MJ, Quinn GE, Belasco JB, Phillips PC, Maguire MG, Balcer LJ.
Am J Ophthalmol. 2011 Mar;151(3):542-549.e2.
USING POPULATION GENOMICS TO DETECT SELECTION IN NATURAL POPULATIONS: KEY CONCEPTS AND METHODOLOGICAL CONSIDERATIONS.
Hohenlohe PA, Phillips PC, Cresko WA.
Int J Plant Sci. 2010 Nov 1;171(9):1059-1071.
Purging deleterious mutations under self fertilization: paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans.
Morran LT, Ohdera AH, Phillips PC.
PLoS One. 2010 Dec 31;5(12).
The genetic landscape of the childhood cancer medulloblastoma.
Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.
Science. 2011 Jan 28;331(6016):435-9.
A phase II study of metronomic oral topotecan for recurrent childhood brain tumors.
Minturn JE, Janss AJ, Fisher PG, Allen JC, Patti R, Phillips PC, Belasco JB.
Pediatr Blood Cancer. 2011 Jan;56(1):39-44.
Selective sweeps and parallel mutation in the adaptive recovery from deleterious mutation in Caenorhabditis elegans.
Denver DR, Howe DK, Wilhelm LJ, Palmer CA, Anderson JL, Stein KC, Phillips PC, Estes S.
Genome Res. 2010 Dec;20(12):1663-71.
A test of the conjecture that G-matrices are more stable than B-matrices.
Barker BS, Phillips PC, Arnold SJ.
Evolution. 2010 Sep;64(9):2601-13.
Genotype to phenotype: a complex problem.
Dowell RD, Ryan O, Jansen A, Cheung D, Agarwala S, Danford T, Bernstein DA, Rolfe PA, Heisler LE, Chin B, Nislow C, Giaever G, Phillips PC, Fink GR, Gifford DK, Boone C.
Science. 2010 Apr 23;328(5977):469.
Outcrossing and the maintenance of males within C. elegans populations.
Anderson JL, Morran LT, Phillips PC.
J Hered. 2010 Mar-Apr;101 Suppl 1:S62-74.
Mutation load and rapid adaptation favour outcrossing over self-fertilization.
Morran LT, Parmenter MD, Phillips PC.
Nature. 2009 Nov 19;462(7271):350-2.
Evolutionary rates and centrality in the yeast gene regulatory network.
Jovelin R, Phillips PC.
Genome Biol. 2009;10(4):R35.
Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans.
Morran LT, Cappy BJ, Anderson JL, Phillips PC.
Evolution. 2009 Jun;63(6):1473-82.
The evolution of sex-determining mechanisms: lessons from temperature-sensitive mutations in sex determination genes in Caenorhabditis elegans.
Chandler CH, Phillips PC, Janzen FJ.
J Evol Biol. 2009 Jan;22(1):192-200.
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis.
Jovelin R, Dunham JP, Sung FS, Phillips PC.
Genetics. 2009 Apr;181(4):1387-97.
What maintains genetic variation in natural populations? A commentary on 'The maintenance of genetic variability by mutation in a polygenic character with linked loci' by Russell Lande.
Genet Res. 2007 Dec;89(5-6):371-2.
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
Nat Rev Genet. 2008 Nov;9(11):855-67.
Beyond induced mutants: using worms to study natural variation in genetic pathways.
Kammenga JE, Phillips PC, De Bono M, Doroszuk A.
Trends Genet. 2008 Apr;24(4):178-85. Epub 2008 Mar 5.
Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study.
Gururangan S, Turner CD, Stewart CF, O'Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, Kun LE.
Clin Cancer Res. 2008 Feb 15;14(4):1124-30.
Evolutionary genetics: who shouldn't be your daddy.
Nature. 2008 Feb 7;451(7179):640-1.
The role of [18F]-fluorodeoxyglucose positron emission tomography in predicting plexiform neurofibroma progression.
Fisher MJ, Basu S, Dombi E, Yu JQ, Widemann BC, Pollock AN, Cnaan A, Zhuang H, Phillips PC, Alavi A.
J Neurooncol. 2008 Apr;87(2):165-71. Epub 2007 Dec 11.