Medical director, Oncology Outpatient Clinic
Assistant professor of Pediatrics, University of Pennsylvania School of Medicine
AddressChildren's Hospital of Philadelphia Colket Translational Research Building Room 10052, Oncology Philadelphia, PA 19104
Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Although 80% of children and adolescents are cured with frontline therapy, 20% of patients relapse and have dismal outcomes. I actively participate in both clinical and translational research programs designed to improve outcomes for this population. I am the institutional principal investigator (PI) for the majority of Children?s Oncology Group (COG), industry, and institutional ALL protocols available at the Children?s Hospital of Philadelphia. I am an active member of the COG Relapsed ALL Strategy Group and am a member of the national study committees for several of the COG relapsed ALL trials.
I see the majority of second opinions referred to CHOP for newly diagnosed and relapsed ALL; as well as, communicate by email and phone with outside pediatric oncologists looking for advice on treatment in complex ALL cases. I oversee the care of all of our patients with ALL enrolled on COG trials as well as those not on study being treated with standard of care.
Since my appointment as Assistant Professor, I have created clinical and translational research programs in childhood and adolescent ALL. These programs include clinical trials for newly diagnosed ALL, supportive care during ALL therapy, and experimental therapeutics for relapsed ALL. I am the institutional principal investigator (PI) for the majority of Children?s Oncology Group (COG), industry, and institutional ALL protocols available at CHOP. I am an active member of the COG Relapsed ALL Committee and am a member of the national study committees for the COG relapsed ALL trials ADVL04P2, AALL0433, and AALL07P1.
I am in my second year of a three year Leukemia Lymphoma Society Translational Research Grant introducing mTOR inhibitors into pediatric clinical trials. A protocol combining temsirolimus with intensive chemotherapy for relapsed ALL and Non-Hodgkin?s Lymphoma (NHL) will be run through the Children?s Oncology Group as a combined protocol between the developmental therapeutics, ALL, and NHL committees, with myself as the National PI. The Leukemia & Lymphoma Society Grant has also let me expand upon an institutional Phase I trial of sirolimus, an oral mTOR inhibitor. Based upon the preclinical work of my co-investigators, Stephen Grupp, MD, PhD and David Teachey, MD, which showed maintenance of complete remission of NOD/SCID mice with ALL using sirolimus and methotrexate, I am PI on an institutional Phase 2 efficacy trial of sirolimus combined with oral methotrexate for children and adolescents with relapsed and refractory ALL and NHL.
The industry sponsored Clofarabine trials, for which I was the local PI, successfully ended with the first new FDA approval for relapsed childhood ALL in over two decades. I have a manuscript in press on a novel combination of chemotherapeutic agents (nelarabine, etoposide, and cyclophosphamide) to treat relapsed T-cell ALL and NHL. Under Eric Kodish, MD (Cleveland Clinic), I am a co-investigator on a R01 funded investigation studying the informed consent process for Phase I pediatric cancer trials.
I also have research interests in oncologic emergencies, supportive care and nutrition/complementary and alternative medicine (CAM) for the pediatric oncology patient, especially as it relates to therapy for children with ALL. In the realm of supportive care and nutrition/CAM for I have collaborated on the following investigations: 1) CAM use in pediatric cancer patients; 2) antioxidant levels and chemotoxicity in ALL patients; 3) milk thistle therapy for hepatotoxicity induced by Maintenance therapy in ALL; 4) erythropoietin use on quality of life; and 5) a pilot study of enteral feeds for high risk pediatric patients. All of these studies have been funded by private foundation grants or industry and several of these studies have now been published. Further grant funding is being sought to run successor trials.
- Associate Professor of Clinical Pediatrics at University of Pennsylvania School of Medicine (2011– present)
- Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (2001 – 2011)
- M.D., University of Pennsylvania School of Medicine (1992)
- B.A., Dartmouth College (magna cum laude) (1988)
Susan R. Rheingold, MD, is an attending physician, Department of Pediatrics, Division of Oncology, at The Children’s Hospital of Philadelphia and assistant professor in Pediatrics at the University of Pennsylvania School of Medicine.
A 1992 graduate of the University of Pennsylvania School of Medicine, Dr. Rheingold completed a residency in pediatrics at John Hopkins Hospital in Baltimore, Maryland and a fellowship in Pediatric Hematology/Oncology at The Children’s Hospital of Philadelphia.
After completing her training in 1999, Dr. Rheingold joined the staff of Children’s Hospital. She currently serves as assistant director of the Oncology outpatient clinic and director of Oncology Education for the Division of Oncology.
Dr. Rheingold’s expertise is in the diagnosis, treatment and biology of acute lymphocytic leukemia (ALL). She serves on the Children’s Oncology Group’s Relapsed ALL Committee, Infant ALL Committee, and the Complementary Therapies Committee. Besides ALL, Dr. Rheingold maintains a special interest in experimental therapeutics and serves as a principal investigator for a Children’s Oncology Group national protocol.
Other interests include complementary and alternative therapies, supportive care for oncology patients undergoing chemotherapy, medical education and rare childhood tumors. Dr. Rheingold is board certified in Pediatrics as well as Pediatric Hematology/Oncology.
- Ladas E, Kennedy D, Rheingold SR, Blumberg J, Tucker K, Kelly K:. Low antioxidant vitamin intake is associated with an increase in adverse effects from chemotherapy in children with acute lymphoblastic leukemia.. American Journal of Clinical Nutrition,. Vol 79. 2004:1029-36.
- Rheingold SR, Meadows AT. Recognition and management of superior vena cava syndrome.. Practical Algorithms in Pediatric Hematology and Oncology. Karger; 2003.
- Shah SS, Manning ML, Leahy E, Magnusson M, Rheingold SR, Bell LM. Central catheter-associated bloodstream infections in pediatric oncology home care. Infection Control and Hospital Epidemiology. Vol 23. 2002:99-102.
- Kodish E, Shaw J, Myers C, Reed M, Drotar D, Rheingold SR, O'Riordan M. Adherence to 6 MP in adolescents with ALL: a multi-method study.. Blood. Vol 100. 2002:759a.
- Rheingold SR. Osteosarcoma and leukocytosis.. The 5 Minute Pediatric Consult. Vol 3rd. Williams and Wilkins; 2002.
- Kim JM, Fang J, Rheingold SR, Grupp SA. Cytoplasmic u heavy chain confers sensitivity to dexamethasone-induced apoptosis in early B lineage cells. Presentation: J Pediatr Heamtol Oncol. Vol 23(3) . 2001:A2.