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Home Research Developmental Therapeutics Peter C. Phillips, MD
Peter C. Phillips, MD
Peter C. Phillips, MD

 

Developmental Therapeutics

  • Clinical outcome in children with recurrent neuroblastoma treated with ABT-751 and effect of ABT-751 on proliferation of neuroblastoma cell lines and on tubulin polymerization in vitro
  • Clinical trial design for target-based therapy
  • Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates
  • Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome
  • Pediatric phase I trial design using maximum target inhibition as the primary endpoint
  • Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors
  • Phase I trial and pharmacokinetic study of ixabepilone administered daily for 5 days in children and adolescents with refractory solid tumors
  • Plasma and CNS pharmacokinetics of O(4)-benzylfolic acid (O (4)BF) and metabolite in a non-human primate model
  • Randomized trial and pharmacokinetic study of pegfilgrastim versus filgrastim after dose-intensive chemotherapy in young adults and children with sarcomas
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